Why wrongly incorporated nucleotide while DNA replication-00201
This subjective question is related to the book/course
vu cs101 Introduction to Computing.
It can also be found in
vu cs101 Mid Term Solved Past Paper No. 1.
Question 1: Why wrongly incorporated nucleotide while DNA replication results in permanent mutation
Answer:
If DNA polymerase incorporates the wrong nucleotide into a newly synthesized DNA strand a single base pair substitution will occure. Another kind of error called strand slippage happens when DNA polymeraseadds an extra nucleotide or skips a nucleotide in the newly synthesized DNA strand, which results respectively in an insertion or deletion. Strand slippage often occures in regions of the genome with repeatitive DNA sequence.
